Amicus Therapeutics US, LLC · Healthcare · United States
Low risk. 3 critical or high findings in Email security, Security headers and 1 other check.
The website for POMBILITI® (cipaglucosidase alfa-atga) + OPFOLDA® (miglustat) is a professionally designed healthcare professional portal operated by Amicus Therapeutics US, LLC. It provides comprehensive clinical data, dosing information, safety warnings, and patient support resources for a specialized pharmaceutical therapy targeting late-onset Pompe disease. The site is clearly targeted at US healthcare professionals and includes links to official prescribing information and patient referral forms. The domain is relatively new, registered in 2022, consistent with the product's market introduction timeline. Technically, the website employs modern tracking and analytics tools such as Google Tag Manager and Microsoft Clarity, alongside a cookie consent mechanism powered by OneTrust, indicating a moderate level of digital maturity and privacy awareness. The site is mobile-optimized, accessible, and SEO-friendly, with a consistent branding approach aligned with the parent company Amicus Therapeutics. Hosting and DNS services are stable, though DNSSEC is not enabled, representing a minor security gap. From a security perspective, the site uses HTTPS and includes cookie consent banners, but lacks explicit security policies or vulnerability disclosure pages. No critical vulnerabilities or exposed sensitive data were detected. The WHOIS data shows domain registration with protections against unauthorized transfer or deletion, supporting legitimacy. Overall, the site demonstrates a solid security posture with room for improvement in DNS security and transparency around incident response. The overall risk assessment is low, with the site serving as a trustworthy source of pharmaceutical information for healthcare professionals. Strategic recommendations include enabling DNSSEC, publishing a security policy or vulnerability disclosure page, and enhancing security headers to further strengthen the security posture.
Scanned
NIS2 Art. 21(2)
This scan rated NIS2 with an earlier keyword method that is no longer shown; rescan for the per-article view. Risk management, continuity, supply chain, training, MFA, management oversight (Art. 20) and incident reporting (Art. 23) need internal evidence, and Guard cannot tell whether NIS2 applies to this organisation.
GDPR is indicative only, based on publicly visible signals: Articles 7, 12, 13 and 32 of Regulation (EU) 2016/679 and Article 5(3) of the ePrivacy Directive. Not a certification or legal assessment.
3 findings rated critical or high. Fix these first.
SPF, DKIM and DMARC stop others sending email that looks like it comes from your domain, a common route to phishing and invoice fraud.
Domain is vulnerable to email spoofing
What to do: Implement SPF, DKIM, and DMARC immediately
Security headers are instructions your web server sends to every visitor’s browser. Missing ones leave visitors more exposed to attacks such as clickjacking and injected scripts.
Controls resources the browser is allowed to load
What to do: Implement a Content-Security-Policy appropriate for your application
TLS encrypts the connection and proves the site is really yours. Weak or expiring certificates trigger browser warnings and put traffic at risk.
Server supports weak protocols: TLSv1.1
What to do: Disable TLS 1.0, TLS 1.1, and all SSL versions
Need hands-on remediation? Email guard@offseq.com
This scan found 19 issues across 6 checks. Monitoring re-runs those checks daily, emails you when something material changes and records each fix, so you can show progress.
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Each check with its score, findings and the evidence it collected.
The security score runs 0–100, higher is better. It is the plain average of the security checks that completed in this scan, each counted equally. A check that could not run is left out: it counts neither as a pass nor as a fail.
Counted in this score
Not counted
Findings that cap the score at 49
Each of these is serious on its own, so while any is present the site cannot rate better than high risk, however good the other checks are.
Partial scans
When the site blocks Guard or most checks cannot run, the score covers only the checks that ran (usually DNS and email), is capped at 75 and is shown as partial, without a risk level.
Risk levels
Leaked credentials and lookalike domains from OffSeq Breach. The counts are free; the detailed lists are paid add-ons.
Leaked records that mention pombilitiopfoldahcp.com, from OffSeq Breach.
No leaked records found
Breach holds no records for pombilitiopfoldahcp.com right now. New leaks arrive continuously, so monitoring on Breach alerts you if that changes.
Business context, site observations and technical notes gathered during the scan, and the standards behind each reference.
Automated reading of the public site. Ratings are indicative.
Reference chips under each finding point to the standard, regulation or specification the finding relates to. They are taken from the official datasets below and mapped conservatively: a finding with no defensible link shows none. NIS2 and GDPR references mark where a finding is relevant evidence, not a compliance verdict. Implementing Regulation (EU) 2024/2690 binds digital infrastructure and digital service providers; for other entities it is the most detailed public reading of the Article 21 measures. WCAG, EN 301 549, European Accessibility Act and Web Accessibility Directive references name the requirement an automated accessibility rule relates to; they are not a conformance verdict.
Retrieved 2026-10-25
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